Superfund Research Program

Shujuan Chen

University of California-San Diego
Laboratory of Environmental Toxicology
Department of Pharmacology, Chemistry & Biochemistry
La Jolla, California 92093

Publications

2023

• Yang X, Weber AA, Mennillo E, Paszek M, Wong S, Le S, Teo JY, Chang M, Benner CW, Tukey RH, Chen S. 2023. Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR. J Biol Chem 299(3):102955. doi:10.1016/j.jbc.2023.102955 PMID:36720308 PMCID:PMC9996368
• Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts P, Tukey RH, Chen S. 2023. Effects of early life oral arsenic exposure on intestinal tract development and lipid homeostasis in neonatal mice: Implications for NAFLD development. Environ Health Perspect 131(9):doi:10.1289/ehp12381 PMID:37668303 PMCID:10478510

2022

• Mennillo E, Yang X, Weber AA, Maruo Y, Verreault M, Barbier O, Chen S, Tukey RH. 2022. Intestinal UDP-glucuronosyltransferase 1A1 and protection against irinotecan-induced toxicity in a novel UDP-glucuronosyltransferase 1A1 tissue-specific humanized mouse model. Drug Metab Dispos 50:33-42. doi:10.1124/dmd.121.000644 PMID:34697081
• Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. 2022. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun 13(1):4346. doi:10.1038/s41467-022-31947-4 PMID:35896521 PMCID:PMC9329322

2021

• van der Schoor LW, Verkade HJ, Bertolini A, de Wit S, Mennillo E, Rettenmeier E, Weber AA, Havinga R, Valaskova P, Jasprova J, Struik D, Bloks VW, Chen S, Schreuder AB, Vitek L, Tukey RH, Jonker JW. 2021. Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia. Sci Rep 11:11107. doi:10.1038/s41598-021-90687-5 PMID:34045606 PMCID:PMC8160219
• Weber AA, Mennillo E, Yang X, van der Schoor LW, Jonker JW, Chen S, Tukey RH. 2021. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. Drug Metab Dispos 49:12-19. doi:10.1124/dmd.120.000240 PMID:33154041 PMCID:PMC7745083

2020

• Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH. 2020. Differential role of LXRa and LXRy in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice. Drug Metab Dispos 48:255-263. doi:10.1124/dmd.119.090068 PMID:31980500 PMCID:PMC7065491
• Mennillo E, Yang X, Paszek M, Auwerx J, Benner CW, Chen S. 2020. NCoR1 protects mice from dextran sodium sulfate-induced colitis by guarding colonic crypt cells from luminal insult. Cell Mol Gastroenterol Hepatol 10:133-147. doi:10.1016/j.jcmgh.2020.01.014 PMID:32044398 PMCID:PMC7229481
• Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. 2020. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 117:31259-31266. doi:10.1073/pnas.2017129117 PMID:33229553 PMCID:PMC7733785

2018

• Chen S, Tukey RH. 2018. Humanized UGT1 mice, regulation of UGT1A1, and the role of the intestinal tract in neonatal hyperbilirubinemia and breast milk-induced jaundice. Drug Metab Dispos 46(11):1745-1755. doi:10.1124/dmd.118.083212 PMID:30093417 PMCID:PMC6199628

2017

• Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 114(8):E1432-E1440. doi:10.1073/pnas.1700232114 PMID:28167773 PMCID:PMC5338369
• Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S. 2017. Crypt organoid culture as an in vitro model in drug metabolism and cytotoxicity studies. Drug Metab Dispos 45:748-754. doi:10.1124/dmd.117.075945 PMID:28468837 PMCID:PMC5478905
• Yoda E, Paszek M, Konopnicki CM, Fujiwara R, Chen S, Tukey RH. 2017. Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep 7:46489. doi:10.1038/srep46489 PMID:28422158 PMCID:PMC5395973
• Yueh MF, Chen S, Nguyen N, Tukey RH. 2017. Developmental, genetic, dietary, and xenobiotic influences on neonatal hyperbilirubinemia. Mol Pharmacol 91(5):545-553. doi:10.1124/mol.116.107524 PMID:28283555 PMCID:PMC5416747

2016

• Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D. 2016. Reduced myelination and increased glia reactivity resulting from severe neonatal hyperbilirubinemia. Mol Pharmacol 89(1):84-93. doi:10.1124/mol.115.098228 PMID:26480925 PMCID:PMC4702100
• Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki CM, Hao H, Tukey RH. 2016. Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol 110-111:37-46. doi:10.1016/j.bcp.2016.04.003 PMID:27060662 PMCID:PMC5010383
• Liu M, Chen S, Yueh MF, Wang G, Hao H, Tukey RH. 2016. Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol Gastroenterol Hepatol 2(1):63-76.e5. doi:10.1016/j.jcmgh.2015.08.008 PMID:26807433 PMCID:PMC4721636
• Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent LC. 2016. Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol 64(6):1315-1326. doi:10.1016/j.jhep.2016.02.028 PMID:26921690 PMCID:PMC5010388

2015

• Fujiwara R, Maruo Y, Chen S, Tukey RH. 2015. Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol 289(1):124-132. doi:10.1016/j.taap.2015.08.018 PMID:26342858 PMCID:PMC4708261

2014

• Yueh MF, Chen S, Nguyen N, Tukey RH. 2014. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem 289(8):4699-4709. doi:10.1074/jbc.M113.518613 PMID:24403077 PMCID:PMC3931032
• Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A 111(48):17200-17205. doi:10.1073/pnas.1419119111 PMID:25404284 PMCID:PMC4260592

2013

• Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. 2013. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A 110(47):19143-19148. doi:10.1073/pnas.1319123110 PMID:24191041 PMCID:PMC3839688

2012

• Chen S, Yueh MF, Evans RM, Tukey RH. 2012. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT 1 mice. Hepatology 56(2):658-667. doi:10.1002/hep.25671 PMID:22371261 PMCID:PMC3383890
• Fujiwara R, Chen S, Karin M, Tukey RH. 2012. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-kappa B leads to hyperbilirubinemia. Gastroenterology 142:109-U259. doi:10.1053/j.gastro.2011.09.045 PMID:21983082 PMCID:PMC3428231

2010

• Cai H, Nguyen N, Peterkin V, Yang Y, Hotz K, La Placa D, Chen S, Tukey RH, Stevens J. 2010. A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation. Drug Metab Dispos 38(5):879-886. doi:10.1124/dmd.109.030130 PMID:20124398 PMCID:PMC2872941
• Fujiwara R, Nguyen N, Chen S, Tukey RH. 2010. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A 107(11):5024-5029. doi:10.1073/pnas.0913290107 PMID:20194756 PMCID:PMC2841904

2008

• Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Belanger A, Tukey RH. 2008. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem 283(12):7901-7911. doi:10.1074/jbc.M709244200 PMID:18180294

2007

• Operana T, Nguyen N, Chen S, Beaton D, Tukey RH. 2007. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci 95(1):98-107. doi:10.1093/toxsci/kfl144 PMID:17065433
• Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. 2007. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos 35(3):419-427. doi:10.1124/dmd.106.013243 PMID:17151188

2005

• Bonzo JA, Chen S, Galijatovic A, Tukey RH. 2005. Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. Mol Pharmacol 67(4):1247-1256. PMID:15630080
• Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH. 2005. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem 280(45):37547-37557. doi:10.1074/jbc.M506683200 PMID:16155002
• Chen S, Operana T, Bonzo JA, Nguyen N, Tukey RH. 2005. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem 280(6):4350-4359. doi:10.1074/jbc.M411554200 PMID:15572374

2004

• Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo JA, Johnson RS, Maeda S, Karin M, Guengerich FP, Tukey RH. 2004. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem 279(23):23969-23976. PMID:15037607

2003

• Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. 2003. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem 278(21):19526-19533. PMID:12637498
• Yueh MF, Huang Y, Hiller A, Chen S, Nguyen N, Tukey RH. 2003. Involvement of the xenobiotic response element (XRE) in ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem 278(17):15001-15006. PMID:12566446